18F-fluorodeoxy-D-glucose positron emission tomography- computed tomography (18F-FDG PET-CT) has become an important diagnostic tool for evaluation of head and neck squamous cell carcinomas (HNSCCs), and is applied in various clinical settings, ranging from pre-treatment staging to radiotherapy planning, treatment response assessment and post-therapy follow-up . Although 18F-FDG is the most commonly used PET tracer for oncologic purposes, its use in HNSCCs suffers from some limitations due to the complex anatomy of this region and the small size of the anatomical structures, as well as the physiological uptake of 18F-FDG in normal organs that may influence image interpretation. 18F-FDG uptake reflects glucose metabolism and can be observed in several normal tissues with wide variability of the normal pattern, including brain, vocal cords, salivary glands, cervical muscles, lymphoid tissue and brown fat, as well as in various benign tumours, such as common Warthin's tumour . Moreover, the inflammatory processes that occur in patients submitted to surgery or radiotherapy are a frequent cause of false positive PET results, since the activated inflammatory cells show increased 18F-FDG uptake . Finally, artefacts related to patient movement or metal dental prostheses may further limit interpretation of PET images, thus requiring non-attenuation corrected PET data evaluation . PET-CT scanners currently allow quick and high resolution imaging, and can correlate anatomical location with functional information. The recent introduction of whole-body PET-magnetic resonance imaging (MRI) in clinical practice offers new opportunities for integrated functional-anatomic imaging . This review will focus on the use of 18F-FDG PET-CT in various clinical scenarios of HNSCCs with attention to PET radiopharmaceuticals other than 18F-FDG, and the new perspectives offered by PET-MRI.
break! Meet bonnie and today i will be reviewing the oatmeal natural shampoo from pet head
you get 354ml of the product :L
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